![]() ![]() Use effective birth control to prevent pregnancy while you are using ribociclib and for at least 3 weeks after your last dose. You may need to have a negative pregnancy test before starting this treatment.ĭo not use ribociclib if you are pregnant. Tell your doctor whether or not you have gone through menopause. Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using ribociclib.Īn electrolyte imbalance (such as low levels of calcium, magnesium, phosphorus, or potassium in your blood) You should not use ribociclib if you are allergic to it, or if you also take tamoxifen. You may report side effects to FDA at 1-80. Call your doctor for medical advice about side effects. ![]() This is not a complete list of side effects and others may occur. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.Ĭommon side effects of ribociclib may include: Liver problems-loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes). Signs of inflammation in the lungs-new or worsening cough, painful or difficult breathing, wheezing, feeling short of breath even while resting or Low white blood cell counts-fever, mouth sores, skin sores, sore throat, cough, trouble breathing Call your doctor at once if you have:įast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out) Ribociclib may cause serious side effects. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Often times, patients with these liver manifestations can be managed with supportive therapies, and liver toxicity may resolve after discontinuation of chemotherapy.Ĭhemotherapy Hepatic Necrosis Hepatic toxicity Hepatitis Pseudocirrhosis Steatosis.Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction ( fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). It is important to anticipate and recognize these adverse reactions and thus appropriate clinical action can be taken. These conditions can display clinical signs of acute hepatitis, liver cirrhosis, and even liver failure. Conditions such as sinusoidal obstructive syndrome, steatosis, and pseudocirrhosis are more commonly associated with chemotherapy. There are several hepatic conditions that can result and keen clinical as well as radiographic recognition are paramount. Cancer chemotherapy has evolved, and newer medications that target cell biology have a different pattern of liver toxicity and may differ from the more traditional cytotoxic agents. It is important for any clinician to have an index of suspicion for liver toxicity and be able to recognize it, even on imaging. Treating patients undergoing chemotherapy who display findings of liver toxicity, requires a solid understanding of these medications.
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